Part I – Pre-analytical phase
Precision oncology relies on pathology to integrate morphological and genomic data for tailored treatment selection. The preanalytical phase, covering all steps from specimen collection to processing before analysis, is one of the major determinants of the quality of downstream molecular analyses, which are essential for selection personalized thera-peutic strategies. Strict adherence to protocols and specific quality control programs are essential to ensure the reliability and standardization of molecular testing. This document intends to guide the multidisciplinary team (pathologists, technicians, molecular biologists) in pathology laboratories during the preparation of samples for molecular analyses.
Authors
- Sara E. Bellomo (ORCID: https://orcid.org/0000-0001-5738-2351)
- Simonetta Buglioni (ORCID: https://orcid.org/0000-0002-5066-1523)
- Umberto Malapelle (ORCID: https://orcid.org/0000-0003-3211-9957)
- Leonardo H. Tonelli (ORCID: https://orcid.org/0000-0002-9272-4959)
- Enrico Berrino (ORCID: https://orcid.org/0000-0001-6728-5619)
- Antonio Giovanni Iaccarino (ORCID: https://orcid.org/0000-0002-7620-921X)
- Nicola Fusco (ORCID: https://orcid.org/0000-0002-9101-9131)
- Stefania Scarpino (ORCID: https://orcid.org/0009-0009-9668-9626)
- Gianluca Witel
- Fabio Pagni (ORCID: https://orcid.org/0000-0001-9625-1637)
- Giuseppe Di Lorenzo (ORCID: https://orcid.org/0000-0001-7414-1568)
- Eliano Cascardi (ORCID: https://orcid.org/0000-0003-1287-4285)
- Caterina Marchiò (ORCID: https://orcid.org/0000-0003-2024-6131)
- Pasquale Pisapia (ORCID: https://orcid.org/0000-0002-6429-0620)
- Greta Alì (ORCID: https://orcid.org/0000-0001-9258-3466)
- Giancarlo Pruneri (ORCID: https://orcid.org/0000-0002-7963-7172)
- Anna Sapino (ORCID: https://orcid.org/0000-0003-3542-9571)
- Elena Guerini-Rocco
- Marzia Nieddu
- Daniela Nobilio
- Andrea Capece
Institutions
- University of Pisa (IT)
- University of Teramo (IT)
- University of Milan (IT)
- Ospedale di Santo Spirito (IT)
- Candiolo Cancer Institute (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- ASM Terni (Italy) (IT)
- University of Turin (IT)
- University of Bari Aldo Moro (IT)
- European Institute of Oncology (IT)
- University of Milano-Bicocca (IT)
- University of Naples Federico II (IT)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- Pathologica
- Published
- 2025-05-09
- DOI
- https://doi.org/10.32074/1591-951x-1215
- Citations
- 4
- Primary Topic
- Molecular Biology Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 3.22
Funders
- AstraZeneca
- Ministero della Salute
- Daiichi Sankyo Europe