Voxel- and surface-based morphometry in the cortical thickness and cortical and subcortical gray matter volume in patients with mild-to-moderate Alzheimer’s disease
In patients with AD, VBM and SBM showed overlapping cortical GMV and CT reductions. Volume/thickness reduction was correlated with lower MMSE/MoCA scores, confirming functional relevance. ROC analysis revealed that combining CT and GMV improved cognitive impairment prediction compared to single measures. This integrated approach may enhance clinical diagnosis and early risk identification of AD.
Authors
- C. D. Fu (ORCID: https://orcid.org/0009-0006-0341-7102)
- Kaidi Li (ORCID: https://orcid.org/0000-0003-2856-9912)
- Dehao Xie
- Zhengyong Zhang (ORCID: https://orcid.org/0000-0001-6644-098X)
- Chunyang Li (ORCID: https://orcid.org/0000-0002-1180-0869)
Institutions
- Inner Mongolia University (CN)
- Xianning Central Hospital (CN)
- Inner Mongolia Autonomous Region Meteorological Bureau (CN)
- Inner Mongolia People's Hospital (CN)
- Inner Mongolia Medical University (CN)
- Henan Medical University (CN)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2025-06-25
- DOI
- https://doi.org/10.3389/fnagi.2025.1546977
- Citations
- 1
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.43
Funders
- Inner Mongolia Medical University
- Natural Science Foundation of Inner Mongolia