IFP35, a novel DAMP, aggravates neuroinflammation following acute ischemic stroke via TLR4/NF-κB/NLRP3 signaling
This study revealed IFP35 as a novel DAMP released during cerebral ischemia that promotes neuroinflammation and injury, expanding the current understanding of inflammatory networks following stroke.
Authors
- Bingnan Guo (ORCID: https://orcid.org/0000-0002-5627-2764)
- Shuqun Hu
- Lanxin Lv
- Xiaoqing Yan (ORCID: https://orcid.org/0000-0003-0120-2379)
- Dong Y. Han (ORCID: https://orcid.org/0000-0003-2794-4151)
- Chenglei Su (ORCID: https://orcid.org/0000-0002-3725-5029)
- Dafei Chai (ORCID: https://orcid.org/0000-0002-8028-2954)
- Xiaowei Zhang (ORCID: https://orcid.org/0009-0004-6021-6134)
- Mengmeng Zhang (ORCID: https://orcid.org/0000-0003-3207-498X)
- Ningjun Zhao
- Xianliang Yan
Institutions
- Xuzhou Medical College (CN)
- Changshu No.1 People's Hospital (CN)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2025-06-25
- DOI
- https://doi.org/10.1186/s12974-025-03492-6
- Citations
- 21
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 17.69
Funders
- Jiangsu Commission of Health
- National Natural Science Foundation of China
- Natural Science Foundation of Jiangsu Province