CIRCADIAN IMMUNITY AND COVID-19: UNVEILING THE SIRT1 CONNECTION

Background: Immunity against infectious diseases, particularly viral infections where antibiotics do not work, plays a key role in their eradication. Therefore, it is essential to identify the natural and biological factors that contribute to a strong immune response to combat COVID-19 and other diseases effectively. Methodology: In this study, we investigated the relationship between the circadian clock, immune function, and the eradication of COVID-19. Also, we evaluate the past research works for the analysis. Results: In this analysis, we examine how SIRT1, circadian clocks, and COVID-19 immunity may interact. Considering that the SIRT1 gene controls the circadian clock, and the circadian clock enhances immunity, therefore, the circadian clock, SIRT1, and the body’s immune defence against coronavirus influence each other in a mutual relationship. Conclusion: Maintaining a healthy sleep and wake routine helps regulate the balance between the circadian clock and cellular immune responses, which is crucial for effectively fighting infections and may aid in recovering from illnesses such as COVID-19.