Regioselective synthesis of C6-alkylated indoles utilizing electronic–steric effects enabled by imino exchange and phosphorus ylide addition
This work reports the regioselective synthesis of C6-alkylated indoles from the dearomatized intermediates of 2-alkynylanilines utilizing electronic effects enabled by imino exchange with alkylamines and steric effects of phosphorus ylide addition.
Authors
- Hao-ting Zhu
- Renhua Fan (ORCID: https://orcid.org/0000-0001-7398-3368)
- Qiuqin He (ORCID: https://orcid.org/0000-0001-9744-9573)
- J.-W. He (ORCID: https://orcid.org/0009-0002-1423-0467)
Institutions
- Fudan University (CN)
- Zhuhai Fudan Innovation Research Institute (CN)
Publication Details
- Journal
- Organic Chemistry Frontiers
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5qo00344j
- Citations
- 1
- Primary Topic
- Synthesis and Catalytic Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.94