<i>In situ</i> oxidizable directing group-enabled enantioselective synthesis of chiral platform ferrocene formaldehydes
Herein, we have developed an efficient oxidatively removable directing group approach, enabling highly enantioselective Pd<sup>II</sup>-catalyzed C-H activation. Successful rationalization of difficult C-H activation over the labile β-H oxidation step led to the direct synthesis of chiral 2-alkenylated ferrocene formaldehydes with up to 71% yields and 98 : 2 er.
Authors
- Devendra Parganiha (ORCID: https://orcid.org/0000-0001-8826-7540)
- Sangit Kumar (ORCID: https://orcid.org/0000-0003-0658-8709)
- Raushan Kumar Jha (ORCID: https://orcid.org/0000-0002-2143-0937)
- Vipin Choudhary (ORCID: https://orcid.org/0009-0003-7862-5334)
- Svastik Jaiswal (ORCID: https://orcid.org/0000-0002-5193-7026)
- Ashwini Dilip Dhumale (ORCID: https://orcid.org/0009-0003-2434-9434)
- Yagya Dutt Upadhyay (ORCID: https://orcid.org/0009-0008-9779-5490)
Institutions
- Indian Institute of Science Education and Research, Bhopal (IN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc02611c
- Citations
- 3
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 2.81
Funders
- Arthritis National Research Foundation
- Department of Science and Technology, Ministry of Science and Technology, India
- Indian Institute of Science Education and Research Bhopal
- Indian Institute of Science Education and Research Mohali