Establishment of a humanized <scp>SCA2</scp> mouse model carrying a <scp>CAA</scp> disruption preventing <scp>CAG</scp> repeat expansion in pathogenic genes
In summary, the establishment of this model not only provides a stable animal model for studying CAG transmission in SCA2 but also indicates that the lack of long-term neural stimulation leads to muscle atrophy.
Authors
- Shaohui Ma (ORCID: https://orcid.org/0000-0002-8992-1177)
- Keqin Lin
- Xiaochao Zhang (ORCID: https://orcid.org/0000-0002-9092-4922)
- Yao Zhang (ORCID: https://orcid.org/0000-0001-5841-225X)
- Ling Zhang (ORCID: https://orcid.org/0000-0002-7917-7671)
- Kai Huang (ORCID: https://orcid.org/0000-0002-9320-0997)
- Hao Sun (ORCID: https://orcid.org/0009-0007-2042-5515)
- Zhaoqing Li (ORCID: https://orcid.org/0000-0001-8649-4934)
- Zhaoqing Yang (ORCID: https://orcid.org/0009-0003-0859-9310)
- Yufei Li
Institutions
- Yunnan University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Kunming Medical University (CN)
- Hebei General Hospital (CN)
- The People's Hospital of LinXia (CN)
Publication Details
- Journal
- Animal Models and Experimental Medicine
- Published
- 2025-06-24
- DOI
- https://doi.org/10.1002/ame2.70047
- Primary Topic
- Genetic Neurodegenerative Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Kunming Medical University
- Chinese Academy of Medical Sciences
- Yunnan Provincial Science and Technology Department