Delivery of LOXL1-AS1-siRNAs using targeting peptide-engineered extracellular vesicles with focused ultrasound to suppress medulloblastoma metastasis
Our study provides the first and very promising evidence for the combined use of tumor-targeted EVs and microbubble-enhanced FUS to deliver therapeutic siRNAs to suppress metastatic MB, potentially supporting conventional treatments and improving clinical outcomes of this malignant pediatric tumor.
Authors
- Le Hien Giang (ORCID: https://orcid.org/0009-0003-5722-2798)
- Che‐Chang Chang (ORCID: https://orcid.org/0000-0001-8080-2094)
- Shing-Shung Chu
- Shian‐Ying Sung (ORCID: https://orcid.org/0000-0002-0078-3899)
- Pei‐Lin Huang (ORCID: https://orcid.org/0000-0001-7861-3745)
- Tai‐Tong Wong (ORCID: https://orcid.org/0000-0003-4075-6227)
- Anh Duy (ORCID: https://orcid.org/0000-0001-7268-4307)
- Chia‐Ling Hsieh (ORCID: https://orcid.org/0000-0002-6649-9030)
- Yu‐Ling Lin (ORCID: https://orcid.org/0000-0003-0299-6588)
Institutions
- Pham Ngoc Thach University of Medicine (VN)
- Hai phong University Of Medicine and Pharmacy (VN)
- Taipei Medical University Hospital (TW)
- University of Medicine and Pharmacy at Ho Chi Minh City (VN)
- Hai Phong University (VN)
- University Medical Center HCMC (VN)
- Chung Shan Medical University Hospital (TW)
- Agricultural Biotechnology Research Center, Academia Sinica (TW)
- Taipei Medical University (TW)
- Chung Shan Medical University (TW)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2025-06-24
- DOI
- https://doi.org/10.1186/s12951-025-03554-0
- Citations
- 1
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Ministry of Health and Welfare
- Ministry of Science and Technology, Taiwan
- Taipei Medical University