Lipoprotein Uptake through Glycosaminoglycans Blocks Ferroptosis in Cancer

Major Finding: Uptake of exogenous lipoproteins through glycosaminoglycans protects cancer cells from ferroptosis.Concept: Lipoproteins inhibit ferroptosis by delivering α-tocopherol, a form of vitamin E, to cancer cells.Impact: Blockade of glycosaminoglycans induces ferroptosis and represents a novel therapeutic target in cancer.

Publication Details

Journal
Cancer Discovery
Published
2025-01-01
DOI
https://doi.org/10.1158/2159-8290.cd-rw2025-057
Primary Topic
Cancer, Lipids, and Metabolism
Type
article
Field-Weighted Citation Impact
0.00
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article

Lipoprotein Uptake through Glycosaminoglycans Blocks Ferroptosis in Cancer

Cancer Discovery
Cancer, Lipids, and Metabolism
article

Lipoprotein Uptake through Glycosaminoglycans Blocks Ferroptosis in Cancer

article en

Abstract

Major Finding: Uptake of exogenous lipoproteins through glycosaminoglycans protects cancer cells from ferroptosis.Concept: Lipoproteins inhibit ferroptosis by delivering α-tocopherol, a form of vitamin E, to cancer cells.Impact: Blockade of glycosaminoglycans induces ferroptosis and represents a novel therapeutic target in cancer.

Cancer Discovery
Good health and well-being
Openalex Percentile: Top 80%
Cancer, Lipids, and Metabolism
DOISourceOpenAlex
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Lipoprotein Uptake through Glycosaminoglycans Blocks Ferroptosis in Cancer · Cancer Discovery (2025) | TGRS Research Map | TGRS