Donor-derived cell-free DNA and miRNA monitoring for the early prediction and diagnosis of liver allograft rejection and patient outcomes
dd-cfDNA and miRNA profiling represent promising noninvasive biomarkers for diagnosing liver graft rejection and dysfunction. The combined use of these biomarkers may result in increased diagnostic accuracy, reduce unnecessary biopsies, and allow personalized immunosuppressive management. Further studies in larger cohorts are needed to validate the clinical applicability of these compounds as diagnostic biomarkers.
Authors
- Constantino Fondevila (ORCID: https://orcid.org/0000-0002-6161-6824)
- Olga Millán (ORCID: https://orcid.org/0000-0002-6861-5832)
- Esther Titos (ORCID: https://orcid.org/0000-0002-2543-2243)
- Pablo Ruíz (ORCID: https://orcid.org/0000-0002-5810-8802)
- Jordi Colmenero (ORCID: https://orcid.org/0000-0001-6024-8479)
- Alba Díaz (ORCID: https://orcid.org/0000-0002-0456-7085)
- Yiliam Fundora (ORCID: https://orcid.org/0000-0003-4950-6988)
- Joan Anton Puig‐Butillé (ORCID: https://orcid.org/0000-0003-4345-9631)
- Mercè Brunet
- J.A. Julian (ORCID: https://orcid.org/0009-0008-7137-9210)
Institutions
- Hospital Universitario La Paz (ES)
- Instituto de Salud Carlos III (ES)
- Hospital La Paz Institute for Health Research (ES)
- Hospital Clínic de Barcelona (ES)
- Institut d'Investigacions Biomèdiques de Barcelona (ES)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- Universitat de Barcelona (ES)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-06-24
- DOI
- https://doi.org/10.3389/fimmu.2025.1604200
- Citations
- 3
- Primary Topic
- Organ Transplantation Techniques and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 6.02
Funders
- Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
- Instituto de Salud Carlos III