Alterations in CNS-derived blood biomarkers during 30 days simulated microgravity
These findings highlight subtle but biologically relevant CNS-related changes in response to different countermeasure strategies during 30-day strict HDTBR. LBNP may enhance metabolite clearance, as reflected in increased Aβ washout. These findings support the use of LBNP as a potential countermeasure to protect brain health during spaceflight and analog missions.
Authors
- Jan‐Niklas Hönemann
- Laura de Boni (ORCID: https://orcid.org/0000-0001-7785-482X)
- Susanne V. Schmidt (ORCID: https://orcid.org/0000-0001-9561-2752)
- Edwin Mulder (ORCID: https://orcid.org/0000-0003-1200-5792)
- Alexandru Odainic (ORCID: https://orcid.org/0000-0002-2806-6904)
- Karsten Heusser (ORCID: https://orcid.org/0000-0002-2571-5585)
- Stefan Moestl
- Jens Jordan
- Christian Liemersdorf (ORCID: https://orcid.org/0000-0001-8407-5226)
- Maria Bohmeier (ORCID: https://orcid.org/0000-0003-3107-9551)
- Petra Frings‐Meuthen (ORCID: https://orcid.org/0000-0001-5291-4419)
- Jens Tank (ORCID: https://orcid.org/0000-0002-5672-1187)
- Benjamin Aretz
Institutions
- University of Bonn (DE)
- University of Cologne (DE)
- University Hospital Bonn (DE)
- Deutsches Zentrum für Luft- und Raumfahrt e. V. (DLR) (DE)
- Institut für Medizinische Biometrie, Informatik und Epidemiologie (DE)
- Peter Doherty Institute (AU)
Publication Details
- Journal
- Frontiers in Physiology
- Published
- 2025-06-24
- DOI
- https://doi.org/10.3389/fphys.2025.1600708
- Primary Topic
- Spaceflight effects on biology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Aeronautics and Space Administration
- Deutsches Zentrum für Luft- und Raumfahrt
- Thiemann Stiftung