Brain-derived neurotrophic factor levels after low-intensity intradialytic cycling aerobic exercise in patients on continuous hemodialysis

Introduction. This study investigated the effect of a 12-week low-intensity cycling aerobic exercise program during hemodialysis on the level of brain-derived neurotrophic factor (BDNF) in end-stage renal disease (ESRD) patients. Methods. A randomized controlled trial was conducted involving 24 ESRD patients receiving continuous hemodialysis. Subjects were randomized to either an intervention group or a control group. The intervention group participated in low-intensity intradialytic cycling aerobic exercise for 30 minutes over 12 weeks, whereas the control group received standard ESRD treatment within the hemodialysis unit. Serum BDNF levels were measured before and after the intervention. Results. A decrease in serum BDNF levels was observed in both groups (p > 0.05) when comparing pre- and post-intervention values. Statistical analysis of the changes (Δ) in BDNF levels between the two groups showed no significant difference (p > 0.05). Conclusion. A 12-week regimen of low-intensity intradialytic cycling aerobic exercise did not lead to an increase in serum BDNF levels among ESRD patients undergoing continuous hemodialysis.