Formulation of Antibacterial Solid Soap Containing Miana Leaf Extract Against Staphylococcus aureus Bacteria

Miana leaf (Coleus scutellarioides (L.) Benth.) is known to contain antibacterial compounds such as flavonoids, tannins, saponins, and alkaloids. This study aimed to formulate solid soap with miana leaf extract at concentrations of 1%, 3%, and 5%, and to evaluate its antibacterial activity against Staphylococcus aureus. The soap formulations were evaluated for organoleptic properties, pH, foam height, skin moisture, and irritation potential. Antibacterial testing was conducted using the well diffusion method. Results showed that the solid soap met physical quality standards, with pH ranging from 9.39 to 10.6, foam height between 7.6 and 14.2 cm, and moisture levels increasing to 36.6–48.4%. Irritation tests revealed no adverse skin reactions. The antibacterial activity test confirmed that all formulations inhibited S. aureus, with the strongest inhibition observed at 5% extract concentration, producing an inhibition zone of 18.4 mm. In conclusion, solid soap containing miana leaf extract is safe for topical use and shows strong antibacterial activity, especially at higher extract concentrations, indicating its potential as a natural antiseptic formulation.

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Publication Details

Journal
Indonesian Journal of Pharmaceutical Education
Published
2025-06-24
DOI
https://doi.org/10.37311/ijpe.v5i2.31146
Primary Topic
Medicinal Plant Research
Type
article
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article

Formulation of Antibacterial Solid Soap Containing Miana Leaf Extract Against Staphylococcus aureus Bacteria

Tamzil Azizi Musdar, Asti Vebriyanti Asjur, Syaifullah Saputro, Mia Wahyu Nuraini et al.
Indonesian Journal of Pharmaceutical Education
Medicinal Plant Research
article

Formulation of Antibacterial Solid Soap Containing Miana Leaf Extract Against Staphylococcus aureus Bacteria

Tamzil Azizi Musdar, Asti Vebriyanti Asjur, Syaifullah Saputro, Mia Wahyu Nuraini, Elvira Santi, Mifta Khaerati Ihsan, Nur Aulia Riski
article en

Abstract

Miana leaf (Coleus scutellarioides (L.) Benth.) is known to contain antibacterial compounds such as flavonoids, tannins, saponins, and alkaloids. This study aimed to formulate solid soap with miana leaf extract at concentrations of 1%, 3%, and 5%, and to evaluate its antibacterial activity against Staphylococcus aureus. The soap formulations were evaluated for organoleptic properties, pH, foam height, skin moisture, and irritation potential. Antibacterial testing was conducted using the well diffusion method. Results showed that the solid soap met physical quality standards, with pH ranging from 9.39 to 10.6, foam height between 7.6 and 14.2 cm, and moisture levels increasing to 36.6–48.4%. Irritation tests revealed no adverse skin reactions. The antibacterial activity test confirmed that all formulations inhibited S. aureus, with the strongest inhibition observed at 5% extract concentration, producing an inhibition zone of 18.4 mm. In conclusion, solid soap containing miana leaf extract is safe for topical use and shows strong antibacterial activity, especially at higher extract concentrations, indicating its potential as a natural antiseptic formulation.

Indonesian Journal of Pharmaceutical EducationVol. 5(2)
Muhammadiyah University of Makassar (ID), Universitas Sembilanbelas November Kolaka (ID), State University of Makassar (ID)
Openalex Percentile: Top 89%
Medicinal Plant Research
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Formulation of Antibacterial Solid Soap Containing Miana Leaf Extract Against Staphylococcus aureus Bacteria — Tamzil Azizi Musdar, Asti Vebriyanti Asjur, et al. · Indonesian Journal of Pharmaceutical Education (2025) | TGRS Research Map | TGRS