Comprehensive immune profiling and predictive modelling of paediatric acute hepatitis of unknown aetiology from a Spanish cohort
Despite the limited cohort analysed, owing to the rarity of cases worldwide, our data provide valuable insights for an accurate, early, and minimally invasive diagnosis of PAHUA. These patients exhibit a distinct immunological profile, with ICs, particularly Gal-9 and sTim-3, showing strong potential as reliable biomarkers.
Authors
- Roberto Lozano‐Rodríguez (ORCID: https://orcid.org/0000-0003-0093-9707)
- Julia del Prado-Montero
- Gema Muñoz‐Bartolo
- Alejandro Pascual‐Iglesias (ORCID: https://orcid.org/0000-0002-2214-5441)
- Cristina Calvo (ORCID: https://orcid.org/0000-0002-6503-3423)
- Eduardo López‐Collazo (ORCID: https://orcid.org/0000-0003-1957-877X)
- Jesús Fernández-Felipe (ORCID: https://orcid.org/0000-0002-3944-0797)
- Verónica Terrón‐Arcos
- Carlos del Fresno (ORCID: https://orcid.org/0000-0003-1771-7254)
- María José Quiles Sebastián (ORCID: https://orcid.org/0000-0001-7136-4870)
- Francisco J. Cueto (ORCID: https://orcid.org/0000-0002-7457-9583)
- Loreto Hierro (ORCID: https://orcid.org/0000-0002-6173-4716)
- Laura Hurtado‐Navarro (ORCID: https://orcid.org/0000-0002-9544-6042)
- E. Frauca
- Paloma Jara (ORCID: https://orcid.org/0000-0002-4669-7929)
- Laura Córdoba-García
- Gonzalo Sáenz de Santa María-Diez
- Daniel Arvelo-Rosario
Institutions
- Universidad Nacional de Educación a Distancia (ES)
- Hospital Universitario La Paz (ES)
- Hospital La Paz Institute for Health Research (ES)
- Centre for Biomedical Network Research on Rare Diseases (ES)
- Centro de Investigación Biomédica en Red (ES)
- Centro de Investigación Biomédica en Red de Cáncer (ES)
- Medical Research Network (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-06-24
- DOI
- https://doi.org/10.3389/fimmu.2025.1599982
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission
- Instituto de Salud Carlos III