Efficacy and safety of HSK21542 for pruritus management in hemodialysis patients: a multicenter, randomized, double-blind, placebo-controlled trial
The 0.3 μg/kg dose of HSK21542 demonstrated superior efficacy and safety in reducing pruritus and improving quality of life in hemodialysis patients.
Authors
- Changlin Mei
- Li Zhou (ORCID: https://orcid.org/0000-0001-6926-8521)
- Min Gao (ORCID: https://orcid.org/0000-0002-0001-5283)
- Tianjun Guan (ORCID: https://orcid.org/0000-0001-9425-1641)
- Dong Sun (ORCID: https://orcid.org/0000-0002-4546-404X)
- Chao-Qing Wu
- Bi‐Cheng Liu (ORCID: https://orcid.org/0000-0002-4584-1853)
- Qinkai Chen (ORCID: https://orcid.org/0000-0002-0375-2860)
- Yan Xu (ORCID: https://orcid.org/0000-0002-7608-7013)
- Rui Yan (ORCID: https://orcid.org/0000-0001-8746-2483)
- Zhanzheng Zhao (ORCID: https://orcid.org/0000-0001-6079-1631)
- Li Yao (ORCID: https://orcid.org/0000-0001-5725-3031)
- Yaming Li
- Hui Xu (ORCID: https://orcid.org/0000-0002-3933-4935)
- Ming Shi (ORCID: https://orcid.org/0000-0002-4690-5695)
- Mingming Pan (ORCID: https://orcid.org/0009-0001-9019-8908)
- Wan‐yun Zhao
Institutions
- Qingdao University (CN)
- Central South University (CN)
- Nanchang University (CN)
- Guiyang Medical University (CN)
- Xuzhou Medical College (CN)
- Second Military Medical University (CN)
- Sichuan University (CN)
- Wuhan University (CN)
- West China Hospital of Sichuan University (CN)
- China National Pharmaceutical Group Corporation (China) (CN)
- Zhongda Hospital Southeast University (CN)
- Affiliated Hospital of Guizhou Medical University (CN)
- The People's Hospital of Guangxi Zhuang Autonomous Region (CN)
- Affiliated Hospital of Qingdao University (CN)
- Zhongshan Hospital of Xiamen University (CN)
- Renmin Hospital of Wuhan University (CN)
- First Hospital of China Medical University (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
- Xiangya Hospital Central South University (CN)
- Shanghai Zhabei District Shibei Hospital (CN)
- First Affiliated Hospital of Nanchang University (CN)
- China Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-06-24
- DOI
- https://doi.org/10.3389/fphar.2025.1583515
- Citations
- 4
- Primary Topic
- Dermatology and Skin Diseases
- Type
- article
- Field-Weighted Citation Impact
- 8.02