Electrolyte‐Free Electrochemical C3‐Arylmethylation of Indoles with Tertiary/Secondary <i>N</i>‐Methyl Anilines using <i>N</i>‐Methyl as the Methylene Source
An electrochemical approach devoid of electrolytes, oxidants, metals, and light is established for the C3‐arylmethylation of indoles using tertiary/secondary N ‐methyl anilines, demonstrating a wide substrate scope, with N ‐methyl serving as the methylene donor. Mechanistic investigations indicate that the presumed C3‐aminomethylated indole acts as a reactive intermediate, facilitating the formation of the arylmethylated product via radical/electrophilic addition, anodic oxidation/deprotonation, fragmentation, and cathodic reduction/protonation processes.
Authors
- Sifeng Li (ORCID: https://orcid.org/0000-0002-5302-1599)
- Chengcheng Fang (ORCID: https://orcid.org/0000-0002-2316-4679)
- Yingqian Xu (ORCID: https://orcid.org/0000-0001-7324-0345)
- Jian Zhen Ou (ORCID: https://orcid.org/0000-0002-6971-2634)
- Haibiao Chen (ORCID: https://orcid.org/0000-0001-9911-0629)
- Yijun Yu (ORCID: https://orcid.org/0000-0002-4006-8072)
- Xiaoqing Liu (ORCID: https://orcid.org/0000-0002-6734-1868)
- Shan Liu (ORCID: https://orcid.org/0009-0002-7792-1513)
- Jie He (ORCID: https://orcid.org/0000-0001-8739-7482)
Institutions
- University of Science and Technology Liaoning (CN)
- Shenzhen Polytechnic University (CN)
Publication Details
- Journal
- Advanced Synthesis & Catalysis
- Published
- 2025-06-24
- DOI
- https://doi.org/10.1002/adsc.9601
- Citations
- 1
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.94