Alkaline Gradient Induced Hydrogen Bond Stabilized Adhesive Dressings for Gastric Ulcer Healing

Abstract Starch‐based dressings offer effective digestive wound care through their mechanical properties and mucosal protection. However, the acidic gastric environment significantly weakens the hydrogen bonding capability of starch hydroxyl groups. This effect not only hinders the formation of stable cross‐linked networks among hydrogel precursor components, but also reduces the tissue adhesion ability of gel dressings. Herein, a hydrogen bond‐stabilizing strategy utilizing nanoscale‐magnesium diboride (MgB 2 NPs) is proposed, which dynamically releases hydroxide ions to establish an alkaline gradient within the starch‐based gel (MBSG). This process not only enhances the electron density of hydrogen bond acceptors inside the gel, but also reduces the ionic dipole interactions between the hydroxyl groups on the gel surface and gastric juice, thereby facilitating the in‐situ generation, stability, and tissue adhesion of MBSG in the gastric environment. MBSG exhibits a 3.96‐fold increase in adhesive force over colloidal bismuth pectin and effectively promotes wound healing by isolating gastric ulcers from excessive H + and inhibiting M1 macrophage activation. This strategy leverages the pathological microenvironment of gastric ulcers to address the mechanical property loss in starch‐based dressings under acidic conditions, offering new insights for wound dressing development.