CHRONIC INFLAMMATION IN DIALYSIS PATIENTS AND ITS CORRELATION WITH DERMATOLOGICAL MANIFESTATIONS: A MULTICENTER STUDY FROM SKOPJE

Introduction: Chronic systemic inflammation is a defining feature in dialysis patients, contributing significantly to dermatological manifestations such as pruritus, xerosis, pigmentation changes, and nail abnormalities. These conditions impair quality of life and are linked to markers of systemic inflammation and dialysis-related factors. Objectives: This study aimed to analyze the prevalence and severity of dermatological manifestations in dialysis patients, and their correlations with systemic inflammation. Methods: An observational, cross-sectional study was conducted in two dialysis centers in Skopje, North Macedonia, involving 167 chronic dialysis patients. Data collection included dermatological assessments, laboratory markers (e.g., CRP, PTH, MPV), and pharmacological histories. Statistical analyses were used to explore correlations. Results: Pruritus was observed in 74% of patients and correlated significantly with CRP (R=0.223, p=0.005) and PTH (R=0.219, p=0.008). Xerosis affected 88.62% of patients, with moderate severity in 38.92%, and correlated with CRP (R=0.215, p=0.003). Pigmentation changes (63.47%) were linked to MPV (R=0.219, p=0.004), while nail abnormalities (81.44%) correlated with ferritin (R=0.170, p=0.028). Conclusion: Dermatological manifestations are prevalent in dialysis patients and closely associated with systemic inflammation markers. A multidisciplinary approach is essential to improve management and patient outcomes.