Effects of dental pulp-derived mesenchymal stem cell exosomes produced under hypoxia conditions on osteoarthritic chondrocytes
Considering that OA is associated with inflammatory components, DPSC exosome produced under hypoxic conditions prevents the formation of proinflammatory cytokines in osteoarthritic chondrocytes and shows therapeutic effects on osteoarthritic chondrocytes. Our study provides the first evidence showing the efficacy of DPSC-derived exosomes produced under hypoxia on osteoarthritic chondrocytes.
Authors
- Zeynep Burçin Gönen (ORCID: https://orcid.org/0000-0003-2725-9330)
- Nur Seda Gökdemir (ORCID: https://orcid.org/0000-0003-0294-7559)
- Recep Saraymen (ORCID: https://orcid.org/0000-0002-6355-2676)
- Hasan Salkın (ORCID: https://orcid.org/0000-0001-9404-2348)
- Habip Karatürk (ORCID: https://orcid.org/0000-0002-8402-0038)
Institutions
- Beykent University (TR)
- Erciyes University (TR)
Publication Details
- Journal
- Connective Tissue Research
- Published
- 2025-06-24
- DOI
- https://doi.org/10.1080/03008207.2025.2519064
- Citations
- 1
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.67