The Importance of the Choline in Chronic Lung Infections

People with chronic lung conditions like COPD and cystic fibrosis are vulnerable to lung infections caused by the bacterium Pseudomonas aeruginosa. These infections are often difficult to treat and can cause sudden worsening of symptoms, known as flare-ups or acute exacerbations. While we know P. aeruginosa triggers inflammation and damage in the lungs, much less is understood about how exactly it causes these flare-ups, or how it survives in such a harsh environment. Dr Sandra Grumelli from the Center of Investigations of Respiratory Diseases in Argentina, has explored the role of a common molecule called choline which is released during infection. Using a combination of mouse models and laboratory experiments, she has discovered that choline not only makes breathing harder, it also helps P. aeruginosa adapt to and persist in the lungs. Her research opens up new possibilities for tackling chronic infections by targeting the bacteria’s energy use and the way it responds to its environment.