Hypothermia as a factor in enhancing the effect of antihypoxants

It is reported that selective hypothermia of organs and tissues reduces the intensity of biological combustion in mitochondria regardless of whether these organs and tissues are associated with the human body (in vivo) or completely isolated from it (in vitro). Therefore, local cooling of a selected part of the body reduces its oxygen demand and prolongs survival under hypoxia, i.e. it has a local antihypoxic effect. General hypothermia of warm-blooded animals and humans can both increase and decrease their survival rate under hypoxia conditions. This is due to the fact that in normal conditions external cooling effect on the organism of a warm-blooded animal increases oxygen-dependent thermogenesis in it. Therefore, in the norm, the process of general cooling of the human body does not contribute to the development of antihypoxic action in it. But oxygen-dependent thermogenesis can be turned off in the hospital setting with special hibernator drugs. Effectively shutting down thermogenesis in the patient’s body before general cooling can provide the antihypoxic activity of general hypothermia. It is shown that at the beginning of the 21st century a group of oxygen-producing antihypoxants, the main ingredient of which is hydrogen peroxide, was discovered in Russia. A formulation of injectable hydrogen peroxide solution intended for local cooling of tissues at the injection site and providing them with oxygen is given. It is shown that injection of the invented cold solution of hydrogen peroxide into soft tissues (myocardium, brain, etc.) provides immediate local antihypoxic action, which develops due to local hypothermia of the tissue at the injection site by means of its physical cooling with cold solution and generation of oxygen gas in it by means of catalase cleavage of hydrogen peroxide into water and molecular oxygen. Since local hypothermia is an unrivaled way to preserve mitochondria during oxygen deprivation, and hydrogen peroxide is the leader among oxygen-producing antihypoxants, modernizing the administration of cold hydrogen peroxide solutions into the brain may in the future provide instant local cooling of the brain with simultaneous local oxygenation.