Toward a Next-Generation Liquid Biopsy for HPV+ HNSCC: Opportunities, Challenges, and the Road Ahead
Human papillomavirus (HPV) whole-genome sequencing-based plasma ctDNA analysis has demonstrated high diagnostic accuracy in identifying HPV-positive head and neck cancer, supporting the potential for future clinical validation through biomarker advancement paradigms. In this issue, we discuss how this research opens exciting future directions for liquid biopsy research and clinical implementation for HPV+ head and neck squamous cell carcinoma. See related article by Bryan et al., p. 3483.
Authors
- Catherine T. Haring (ORCID: https://orcid.org/0000-0002-9317-6536)
- Melina J. Windon (ORCID: https://orcid.org/0000-0002-0904-2931)
- J. Chad Brenner (ORCID: https://orcid.org/0000-0003-3238-1111)
- Molly E. Heft Neal (ORCID: https://orcid.org/0000-0002-8813-5537)
Institutions
- University of Kentucky (US)
- University of Michigan (US)
- Michigan Medicine (US)
- Michigan Center for Translational Pathology (US)
- The Ohio State University (US)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-06-24
- DOI
- https://doi.org/10.1158/1078-0432.ccr-25-1488
- Primary Topic
- Molecular Biology Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00