AAnet Resolves a Continuum of Spatially Localized Cell States to Unveil Intratumoral Heterogeneity
Defining critical cell states among cells that reside along a phenotypic continuum is a current biological and computational challenge. In this study, we present AAnet, a neural network that learns archetypal cell states of cancer cells. AAnet defines discrete spatially localized ATs that resolve intratumoral heterogeneity.
Authors
- John G. Lock (ORCID: https://orcid.org/0000-0002-3880-4106)
- Beatriz P. San Juan (ORCID: https://orcid.org/0000-0002-7868-6298)
- Matthew Amodio (ORCID: https://orcid.org/0000-0001-9478-0957)
- David van Dijk (ORCID: https://orcid.org/0000-0003-3911-9925)
- Andrew Benz (ORCID: https://orcid.org/0009-0002-8118-1861)
- Scott E. Youlten (ORCID: https://orcid.org/0000-0001-9314-2945)
- Leonard D. Goldstein (ORCID: https://orcid.org/0000-0003-4645-553X)
- Aarthi Venkat (ORCID: https://orcid.org/0000-0003-0298-0172)
- Daniel Neumann (ORCID: https://orcid.org/0000-0001-6079-0831)
- Smita Krishnaswamy (ORCID: https://orcid.org/0000-0001-5823-1985)
- Sarah Kummerfeld (ORCID: https://orcid.org/0000-0002-0089-2358)
- Joakim Lundeberg (ORCID: https://orcid.org/0000-0003-4313-1601)
- Shabarni Gupta (ORCID: https://orcid.org/0000-0002-8233-5917)
- Jeff Holst (ORCID: https://orcid.org/0000-0002-0377-9318)
- Daniel B. Burkhardt (ORCID: https://orcid.org/0000-0001-7744-1363)
- Christine L. Chaffer (ORCID: https://orcid.org/0000-0003-2620-6130)
- Carley A. Purcell (ORCID: https://orcid.org/0000-0003-2255-6774)
- Cerys S. McCool
- Annelie Mollbrink (ORCID: https://orcid.org/0009-0007-0542-0695)
- Anton E. Westacott
Institutions
- Broad Institute (US)
- Nvidia (United Kingdom) (GB)
- Garvan Institute of Medical Research (AU)
- Somerville Hospital (US)
- UNSW Sydney (AU)
- Yale University (US)
- St Vincent's Hospital Sydney (AU)
- St Vincent's Clinic (AU)
- KTH Royal Institute of Technology (SE)
Publication Details
- Journal
- Cancer Discovery
- Published
- 2025-06-24
- DOI
- https://doi.org/10.1158/2159-8290.cd-24-0684
- Citations
- 2
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 2.09
Funders
- National Science Foundation
- Yale University
- Gruber Foundation
- Yale Cancer Center
- Broad Institute
- University of New South Wales
- Cancerfonden
- Tour de Cure
- National Health and Medical Research Council