Accurate Detection of Cerebrospinal Fluid by DNA Aptamers Derived by Clinical Samples
Novel DNA aptamers CSF-APT-1 and CSF-APT-2 accurately detected cerebrospinal fluid (CSF) in 19 patient samples. Sequencing confirmed CSF-APT-1 and CSF-APT-2 as superior CSF detection probes over other candidates from the same in vitro selection. Use of CSF-APT-1 and CSF-APT-2, which are specific to CSF, may offer improvements in speed and accuracy compared to current CSF diagnostics.
Authors
- Michelle Khine (ORCID: https://orcid.org/0000-0003-0957-8194)
- Brandon Latifi (ORCID: https://orcid.org/0000-0002-8309-8490)
- Edward C. Kuan (ORCID: https://orcid.org/0000-0003-3475-0718)
- Frank P. K. Hsu (ORCID: https://orcid.org/0000-0003-0929-4052)
- Arash Abiri (ORCID: https://orcid.org/0000-0003-2656-1060)
- Mehmet Şenel (ORCID: https://orcid.org/0000-0001-7366-4746)
- Andrej Lupták (ORCID: https://orcid.org/0000-0002-0632-5442)
- Xinlei Chen (ORCID: https://orcid.org/0009-0002-5828-7027)
- Dana Kadifa
- Yana Khetiya
Institutions
- University of California, Irvine (US)
- Irvine University (US)
- Neurological Surgery (US)
Publication Details
- Journal
- International Forum of Allergy & Rhinology
- Published
- 2025-06-24
- DOI
- https://doi.org/10.1002/alr.23624
- Citations
- 2
- Primary Topic
- Advanced biosensing and bioanalysis techniques
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- American Rhinologic Society
- School of Medicine, University of California, Irvine