Comparison of human transplacental transfer of escitalopram, sertraline and paroxetine: an ex vivo cotyledon perfusion study
The present study is the first one that compared the human placental transfer of escitalopram, sertraline and paroxetine, using the same conditions of ex vivo perfusion. Our results are consistent with in vivo data, confirming the relevance of ex vivo placental perfusion for evaluating transplacental transfer, and highlighting the importance of adding albumin to the perfusion medium, particularly for highly protein-bound drugs.
Authors
- Frantz Foissac (ORCID: https://orcid.org/0000-0002-9928-3404)
- Sihem Benaboud
- Saı̈k Urien (ORCID: https://orcid.org/0000-0002-1065-0600)
- Laure‐Hélène Préta (ORCID: https://orcid.org/0000-0002-3141-5925)
- Gabrielle Lui (ORCID: https://orcid.org/0000-0002-6529-0024)
- Naïm Bouazza (ORCID: https://orcid.org/0000-0002-2158-1399)
- Jean‐Marc Tréluyer (ORCID: https://orcid.org/0000-0002-2045-4742)
- Victoria Buth
- Léo Froelicher Bournaud (ORCID: https://orcid.org/0009-0001-3950-7728)
- Annouk Dauvilliers
- Alisha Dinnall
Institutions
- Inserm (FR)
- Université Paris Cité (FR)
- Sorbonne Paris Cité (FR)
- Hôpital Cochin (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Maternité Port Royal (FR)
- Groupe Hospitalier Cochin - Port-Royal, Hôtel-Dieu, Broca - La Collégiale (FR)
Publication Details
- Journal
- Placenta
- Published
- 2025-06-24
- DOI
- https://doi.org/10.1016/j.placenta.2025.06.015
- Citations
- 3
- Primary Topic
- Maternal Mental Health During Pregnancy and Postpartum
- Type
- article
- Field-Weighted Citation Impact
- 5.64