Loeys-Dietz syndrome subtypes exhibit distinct clinical behavior and aortic cellular transcriptomic profiles
Loeys-Dietz syndrome subtypes may demonstrate variable clinical outcomes after aortic root replacement. Distinct gene dysregulation patterns suggest varying smooth muscle cell-extracellular matrix interactions may participate in clinical variation.
Authors
- Michael P. Fischbein (ORCID: https://orcid.org/0000-0002-0638-2025)
- D. Craig Miller (ORCID: https://orcid.org/0000-0001-7619-0080)
- Matthew M. Duda (ORCID: https://orcid.org/0000-0003-1442-7614)
- Albert J Pedroza (ORCID: https://orcid.org/0000-0001-5291-5980)
- Casey Gilles (ORCID: https://orcid.org/0009-0008-3527-629X)
- Alex R. Dalal (ORCID: https://orcid.org/0000-0002-9993-3817)
- Emily Tognozzi
- Jennifer Kim (ORCID: https://orcid.org/0000-0002-8937-8637)
Institutions
- Stanford University (US)
Publication Details
- Journal
- JTCVS Open
- Published
- 2025-06-24
- DOI
- https://doi.org/10.1016/j.xjon.2025.06.013
- Citations
- 1
- Primary Topic
- Connective tissue disorders research
- Type
- article
- Field-Weighted Citation Impact
- 1.82
Funders
- National Institutes of Health