When families bridge the research-clinical divide: An exploration of values regarding cascade screening in genomic research
Ethical tensions and logistical hurdles arise when considering CS that bridges research and clinical settings. Additional study of the appropriateness and feasibility of testing for relatives, especially in genomics in which distinctions between research and clinical care are often blurred, is needed.
Authors
- Hadley Stevens Smith (ORCID: https://orcid.org/0000-0003-1247-6535)
- Mary A. Majumder (ORCID: https://orcid.org/0000-0002-5025-3618)
- Stephanie M. Fullerton (ORCID: https://orcid.org/0000-0002-0938-6048)
- Laura M. Amendola (ORCID: https://orcid.org/0000-0002-5506-6168)
- Sara Ackerman (ORCID: https://orcid.org/0000-0003-3567-7698)
- Eimear E. Kenny (ORCID: https://orcid.org/0000-0001-9198-759X)
- Candice R. Finnila
- Stephanie A. Kraft (ORCID: https://orcid.org/0000-0002-2862-7601)
- Benjamin S. Wilfond (ORCID: https://orcid.org/0000-0002-2671-9860)
- Katherine E. Bonini (ORCID: https://orcid.org/0000-0001-7721-8137)
- Amy L. McGuire (ORCID: https://orcid.org/0000-0002-7819-519X)
- Nuriye Sahin‐Hodoglugil
- Ann Katherine M. Foreman (ORCID: https://orcid.org/0000-0002-0293-6609)
- Lauren Desrosiers (ORCID: https://orcid.org/0000-0002-0991-8155)
Institutions
- University of North Carolina at Chapel Hill (US)
- Geisinger Medical Center (US)
- Harvard University (US)
- University of California, San Francisco (US)
- Baylor College of Medicine (US)
- University of Washington (US)
- University of Washington Medical Center (US)
- Center for Practical Bioethics (US)
- Seattle Children's Hospital (US)
- Harvard Pilgrim Health Care (US)
- HudsonAlpha Institute for Biotechnology (US)
- Texas Children's Hospital (US)
- Children's Cancer Center (US)
- Genomic Health (United States) (US)
- Geisinger Health System (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Genetics in Medicine Open
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.gimo.2025.103440
- Primary Topic
- BRCA gene mutations in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Human Genome Research Institute