Multidimensional Analysis of B7 Homolog 3 RNA Expression in Small Cell Lung Cancer Molecular Subtypes
B7-H3 showed consistent, high expression across SCLC molecular subtypes, whereas DLL3 and SEZ6 expression varied significantly. These data suggest that B7-H3-targeting antibody-drug conjugates may be active across SCLC subtypes, consistent with the high reported response rates.
Authors
- Xiaozhong Qian (ORCID: https://orcid.org/0009-0002-5951-2230)
- Simon Heeke (ORCID: https://orcid.org/0000-0002-5916-534X)
- Taofeek K. Owonikoko (ORCID: https://orcid.org/0000-0002-7724-7728)
- Noura J. Choudhury (ORCID: https://orcid.org/0000-0002-5980-4973)
- Zachary Cain
- Charles M. Rudin (ORCID: https://orcid.org/0000-0001-5204-3465)
- Carl M. Gay (ORCID: https://orcid.org/0000-0002-4907-0718)
- Sharon Wu (ORCID: https://orcid.org/0009-0004-3451-2247)
- Lauren A. Byers (ORCID: https://orcid.org/0000-0002-0780-2677)
- Matthew Brentnall
- Ming Jye Poi (ORCID: https://orcid.org/0000-0001-6065-8662)
- S. Faisal Ahmed
Institutions
- University of Maryland, Baltimore (US)
- Memorial Sloan Kettering Cancer Center (US)
- The University of Texas MD Anderson Cancer Center (US)
- UPMC Hillman Cancer Center (US)
- Caris Life Sciences (United States) (US)
- Daiichi Sankyo (United States) (US)
- University of Baltimore (US)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-06-24
- DOI
- https://doi.org/10.1158/1078-0432.ccr-24-3981
- Citations
- 5
- Primary Topic
- Lung Cancer Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 5.23