MTA-Cooperative PRMT5 Inhibitors Are Efficacious in MTAP-Deleted Malignant Peripheral Nerve Sheath Tumor Models
Clinical-stage MTA-cooperative PRMT5 inhibitors TNG908 and TNG462 are efficacious in MPNST models in vitro and in vivo; therefore, MTA-cooperative PRMT5 inhibitors are promising therapeutic agents for patients with MTAP-deleted MPNSTs. See related commentary by Sheehan et al., p. 4620.
Authors
- Xiaochun Zhang (ORCID: https://orcid.org/0000-0002-6107-1182)
- Minjie Zhang (ORCID: https://orcid.org/0000-0003-1778-3761)
- Kevin M. Cottrell (ORCID: https://orcid.org/0009-0008-6511-0696)
- Kevin He (ORCID: https://orcid.org/0000-0003-2642-7830)
- John P. Maxwell (ORCID: https://orcid.org/0000-0002-5969-6490)
- Dana C. Borcherding (ORCID: https://orcid.org/0000-0002-8849-2139)
- Angela C. Hirbe (ORCID: https://orcid.org/0000-0003-1719-0771)
- Heather DiBenedetto (ORCID: https://orcid.org/0009-0005-0211-8154)
- Alan Huang (ORCID: https://orcid.org/0000-0001-5501-0212)
- Anthony P.W. Yuen (ORCID: https://orcid.org/0009-0004-9680-8625)
- Yang Lyu (ORCID: https://orcid.org/0000-0002-4353-0082)
- Kuangying Yang (ORCID: https://orcid.org/0000-0002-6992-9585)
- Alice Tsai (ORCID: https://orcid.org/0009-0004-0728-3637)
- Kimberly J. Briggs (ORCID: https://orcid.org/0009-0007-4564-6576)
- Liuzhan Yang (ORCID: https://orcid.org/0009-0002-9718-4768)
- Guangfeng Wang (ORCID: https://orcid.org/0009-0007-0735-330X)
- Ishita Sachdeva (ORCID: https://orcid.org/0009-0006-9686-6432)
- Gorkem Oztosun (ORCID: https://orcid.org/0000-0002-8374-4405)
Institutions
- Washington University in St. Louis (US)
- Tango Therapeutics (United States) (US)
- Io Therapeutics (United States) (US)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-06-24
- DOI
- https://doi.org/10.1158/1078-0432.ccr-24-3610
- Citations
- 1
- Primary Topic
- Cancer-related gene regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00