Pre-Existing Anti-Inflammatory Immune Conditions Influence Early Antibody Avidity and Isotype Profile Following Comirnaty® Vaccination in Mice
Prior exposure to <i>F. hepatica</i> antigens can modulate the early immune response to Comirnaty<sup>®</sup>, affecting both cellular activation and antibody quality. This altered response may reflect a reduced early protective capacity of the vaccine, which might need to be considered when designing or evaluating vaccination strategies using mRNA vaccines in helminth-endemic regions.
Authors
- María Cruz Miraglia
- Florencia Celeste Mansilla (ORCID: https://orcid.org/0000-0002-8325-0579)
- Cecilia P. Randazzo
- Alejandra Victoria Capozzo
- Teresa Freire (ORCID: https://orcid.org/0000-0002-7808-8845)
- Mariangeles Castillo
- Leticia V. Bentancor
Institutions
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- Universidad de la República de Uruguay (UY)
- Universidad Abierta Interamericana (AR)
Publication Details
- Journal
- Vaccines
- Published
- 2025-06-24
- DOI
- https://doi.org/10.3390/vaccines13070677
- Primary Topic
- Immune responses and vaccinations
- Type
- article
- Field-Weighted Citation Impact
- 0.00