Comparative analyses of Weibull model and conventional kinetics models of drug release of formulated multi-component tablets

The Kinetics study of drug release is an essential requirement to examine the capability of the drug formulation to modulate with the typical drug release profile. In the present work, hence, Weibull model and other traditional drug release models are selected to investigate the release of tablets prepared using different drying techniques in a simulated abdominal solution. These tablets are prepared using electromagnetic microwave irradiation tablet (MVT), convective drying (CVT), freeze drying (FRT), vacuum drying (VAT), and that without drying process (NDT). This study aims to compare the Weibull models with other conventional drug release models in inspecting the kinetics of the drug release of all tablets. These models are the Zero-Order, Higuchi, First-Order, Hixson-Crowell, and Korsmeyer-Peppas. This work delves into the best kinetic model that defined the tablets' release mechanisms including the new multi-component tablets (MVT), to ensure their releases are on appropriate behavior. The results show that the Weibull model is the best model to present the release profile of all tablets except for MVT and VAT tablets, while Higuchi gets the optimal model. Among the conventional models, Higuchi, Korsmeyer-Peppas, and Hixon-Crowell are the best conventional models that fit all types of tablets. Based on the Weibull model factor, non-Fickian diffusion is the dominant release mechanism for NDT and VAT. Though Fick diffusion controls the drug release mechanism of FTR, CVT, and MVT tablets. Additionally, three modified models were created and found to be more convenient to denote the release of the formulated tablets with very high accuracy.