Insulin-like growth factor 1 as a diagnostic marker of progressive central precocious puberty: a prospective study
• This prospective study suggests IGF1-SDS >1.44 as accurate cut-off for progressive CPP via the IMMULITE assay. • IGF1-SDS show high specificity and diagnostic accuracy, supporting its use in the initial diagnostic approach for girls presenting with early pubertal signs.
Authors
- Luís Filipe Azevedo (ORCID: https://orcid.org/0000-0002-8421-2937)
- Maria Adriana Rangel (ORCID: https://orcid.org/0000-0002-6130-2446)
- Ana Luísa Leite (ORCID: https://orcid.org/0000-0003-2616-5324)
- Sónia Aires
- João Firmino‐Machado (ORCID: https://orcid.org/0000-0001-9410-633X)
- Catarina Limbert (ORCID: https://orcid.org/0000-0002-7455-4538)
- F De Los Santos (ORCID: https://orcid.org/0000-0002-5791-719X)
- Rosa Arménia Campos (ORCID: https://orcid.org/0000-0002-6654-4460)
- C. A. A. Torres
Institutions
- University of Lisbon (PT)
- Universidade do Porto (PT)
- Centro Tecnológico do Calçado de Portugal (PT)
- Unidade Local de Saúde de Entre Douro e Vouga (PT)
- Administração Regional de Saúde de Lisboa e Vale do Tejo (PT)
- Hospital de Dona Estefânia (PT)
- Centre for Health Technology and Services Research (PT)
- Centro Hospitalar de Vila Nova de Gaia (PT)
- University of Aveiro (PT)
- Universidade Nova de Lisboa (PT)
Publication Details
- Journal
- European Journal of Pediatrics
- Published
- 2025-06-24
- DOI
- https://doi.org/10.1007/s00431-025-06276-5
- Primary Topic
- Growth Hormone and Insulin-like Growth Factors
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Universidade do Porto