T Cell–Mediated Immunity to Gliadin Is Elicited in the Gut Mucosa of Type 1 Diabetes Patients Only in Presence of Celiac Disease Comorbidity

It has been hypothesized that dietary proteins act as environmental factors in type 1 diabetes pathogenesis. This study investigated whether gliadin-specific T cells are present in the small intestine of children with type 1 diabetes, without or with celiac disease comorbidity. No sign of gliadin-reactive T cells, either proinflammatory or regulatory, was observed in the gut mucosa of children with type 1 diabetes negative for celiac disease autoimmunity. Interferon-γ-producing T cells were detected in gut mucosa biopsy specimens of children with diabetes seropositive for antitissue transglutaminase antibodies. Our study does not support a pathogenic role of intestinal T cell-mediated immunity to gluten in type 1 diabetes pathogenesis.

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Publication Details

Journal
Diabetes
Published
2025-06-24
DOI
https://doi.org/10.2337/db24-1120
Citations
1
Primary Topic
Celiac Disease Research and Management
Type
article
Field-Weighted Citation Impact
1.81

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article

T Cell–Mediated Immunity to Gliadin Is Elicited in the Gut Mucosa of Type 1 Diabetes Patients Only in Presence of Celiac Disease Comorbidity

Riccardo Troncone, Adriana Franzese, Renata Auricchio, Alessandra Camarca et al.
1 citations
Diabetes
Celiac Disease Research and Management
1.81
article

T Cell–Mediated Immunity to Gliadin Is Elicited in the Gut Mucosa of Type 1 Diabetes Patients Only in Presence of Celiac Disease Comorbidity

Riccardo Troncone, Adriana Franzese, Renata Auricchio, Alessandra Camarca, Mariantonia Maglio, Silvia Gregori, Serena Vitale, Carmen Gianfrani, Ilaria Mottola, Martina Carpinelli, Stefania Picascia
article en
1 citations

Abstract

It has been hypothesized that dietary proteins act as environmental factors in type 1 diabetes pathogenesis. This study investigated whether gliadin-specific T cells are present in the small intestine of children with type 1 diabetes, without or with celiac disease comorbidity. No sign of gliadin-reactive T cells, either proinflammatory or regulatory, was observed in the gut mucosa of children with type 1 diabetes negative for celiac disease autoimmunity. Interferon-γ-producing T cells were detected in gut mucosa biopsy specimens of children with diabetes seropositive for antitissue transglutaminase antibodies. Our study does not support a pathogenic role of intestinal T cell-mediated immunity to gluten in type 1 diabetes pathogenesis.

DiabetesVol. 74(9)
Institute of Food Science (IT), Federico II University Hospital (IT), Institute for Experimental Endocrinology and Oncology (IT), The San Raffaele Telethon Institute for Gene Therapy (IT), Istituti di Ricovero e Cura a Carattere Scientifico (IT), National Research Council (IT), Institute of Cell Biology and Neurobiology (IT), Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele (IT)
Ministero della Salute, Fondazione Celiachia
Good health and well-being
Openalex Percentile: Top 16%
Celiac Disease Research and Management
1.81
DOISourceOpenAlex
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