Genetic markers for knee osteoarthritis presence are not associated with disease progression - data from the IMI-APPROACH cohort
The 30 OA risk SNPs individually and combined in a PRS are not associated with progression of knee OA in the IMI-APPROACH cohort. 19 different SNPs were associated with minJSW decrease. We demonstrated how to employ multiple bioinformatics tools to, despite a limited dataset, still prioritise potential biomarkers for associations to knee OA progression.
Authors
- Francisco Javier Blanco (ORCID: https://orcid.org/0000-0001-9821-7635)
- S.C. Mastbergen (ORCID: https://orcid.org/0000-0002-8825-6486)
- Mylène P. Jansen (ORCID: https://orcid.org/0000-0003-1929-6350)
- Said el Bouhaddani (ORCID: https://orcid.org/0000-0002-2279-4337)
- Philippe Moingeon (ORCID: https://orcid.org/0000-0002-2380-9983)
- Hae‐Won Uh (ORCID: https://orcid.org/0000-0003-4195-7872)
- Francis Bérenbaum (ORCID: https://orcid.org/0000-0001-8252-7815)
- I.K. Haugen (ORCID: https://orcid.org/0000-0001-7810-2216)
- M. Kloppenburg (ORCID: https://orcid.org/0000-0002-9294-2307)
- Mieke L M Bentvelzen (ORCID: https://orcid.org/0009-0003-5054-1569)
Institutions
- Inserm (FR)
- Université Paris-Saclay (FR)
- Leiden University Medical Center (NL)
- CEA Paris-Saclay - Etablissement de Saclay (FR)
- University Medical Center Utrecht (NL)
- Sorbonne Université (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Diakonhjemmet Hospital (NO)
- Centre de Recherche Saint-Antoine (FR)
- Complexo Hospitalario Universitario A Coruña (ES)
- Instituto de Investigación Biomédica de A Coruña (ES)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-06-24
- DOI
- https://doi.org/10.1371/journal.pone.0325819
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Innovative Medicines Initiative