Diagnosing Organ Involvement in Juvenile Systemic Sclerosis with <sup>68</sup>Ga-FAPI-46 PET/CT
We sought to assess the diagnostic value of <sup>68</sup>Ga-fibroblast activation protein inhibitor (FAPI)-46 PET/CT for obtaining information on organ involvement in the process of inflammation and fibrosis in patients with juvenile systemic sclerosis (jSSc). <b>Methods:</b> In this retrospective study, 4 children with a diagnosis of jSSc underwent <sup>68</sup>Ga-FAPI-46 PET/CT imaging, 3 immediately after the diagnosis and before implementing immunmodulatory drugs and 1 a few years after active disease. <b>Results:</b> In this case series, <sup>68</sup>Ga-FAPI-46 PET/CT detected all clinically known organ manifestations of jSSc. Additionally, this diagnostic tool provided previously unknown information about cardiac and muscular involvement in jSSc. <b>Conclusion:</b> <sup>68</sup>Ga-FAPI-46 PET/CT provides valuable information to better assess disease activity and detect organ involvement. Further studies using <sup>68</sup>Ga-FAPI-46 PET/CT in patients with jSSc are encouraged.
Authors
- Armin Atzinger
- Klaus Engel (ORCID: https://orcid.org/0009-0001-1423-898X)
- Christian Schmidkonz (ORCID: https://orcid.org/0000-0002-1988-0058)
- Torsten Kuwert (ORCID: https://orcid.org/0000-0001-5682-8139)
- Joachim Woelfle (ORCID: https://orcid.org/0000-0002-9132-6174)
- Tobias Krickau (ORCID: https://orcid.org/0009-0002-2675-7610)
- Michael Beck (ORCID: https://orcid.org/0000-0003-2523-6266)
Institutions
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Universitätsklinikum Erlangen (DE)
- Siemens Healthineers (Germany) (DE)
Publication Details
- Journal
- Journal of Nuclear Medicine Technology
- Published
- 2025-06-24
- DOI
- https://doi.org/10.2967/jnmt.125.269645
- Citations
- 1
- Primary Topic
- Peptidase Inhibition and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 1.05