Hyalinization-based pathologic response and immune infiltration following neoadjuvant radiotherapy with or without immune-checkpoint blockade in localized undifferentiated pleomorphic sarcoma
HPR was significantly associated with improved overall and recurrence-free survival, regardless of treatment, although use of ICB led to better outcomes. These findings support the need to explore the role of ICB with chemotherapy and RT to enhance UPS treatment strategies.
Authors
- Diana D. Shamsutdinova (ORCID: https://orcid.org/0000-0003-1057-1731)
- SHREYASKUMAR R. PATEL (ORCID: https://orcid.org/0000-0002-0026-2348)
- Andrew Justin Bishop (ORCID: https://orcid.org/0000-0002-7737-8023)
- Ravin Ratan (ORCID: https://orcid.org/0000-0002-4914-7922)
- Christopher P. Scally
- A.K. Yoder
- Raymond Traweek
- Dejka M. Araujo (ORCID: https://orcid.org/0000-0002-1223-6542)
- Kelly K. Hunt (ORCID: https://orcid.org/0000-0001-9156-8723)
- Devarati Mitra (ORCID: https://orcid.org/0000-0002-2225-164X)
- Davis R. Ingram (ORCID: https://orcid.org/0000-0001-5967-1501)
- Khalida Wani (ORCID: https://orcid.org/0000-0002-2383-3908)
- Mohamad El Zoghbi (ORCID: https://orcid.org/0000-0002-5487-1827)
- Rossana Lazcano (ORCID: https://orcid.org/0000-0001-9890-2325)
- Ahsan Saleem Farooqi (ORCID: https://orcid.org/0000-0001-9605-7113)
- Alexander J. Lazar (ORCID: https://orcid.org/0000-0002-6395-4499)
- B. Ashleigh Guadagnolo (ORCID: https://orcid.org/0000-0002-4489-7070)
- Vinod Ravi (ORCID: https://orcid.org/0000-0001-6080-9336)
- Brandon Cope
- Maria A. Zarzour (ORCID: https://orcid.org/0000-0002-6474-7731)
- Keila E. Torres (ORCID: https://orcid.org/0000-0002-1855-0989)
- Mitsuru Nakazawa (ORCID: https://orcid.org/0000-0001-6095-5712)
- Emily Z. Keung (ORCID: https://orcid.org/0000-0002-8783-8484)
- Elise F. Nassif (ORCID: https://orcid.org/0000-0003-3794-6759)
- Christina Lynn Roland (ORCID: https://orcid.org/0000-0003-3400-0087)
- J. Andrew Livingston (ORCID: https://orcid.org/0000-0002-1337-3282)
- Neeta Somaiah (ORCID: https://orcid.org/0000-0002-0146-7732)
- Anthony P. Conley (ORCID: https://orcid.org/0000-0002-6232-1163)
- Wenlong Wang (ORCID: https://orcid.org/0000-0001-8355-3863)
Institutions
- The University of Texas MD Anderson Cancer Center (US)
- Massachusetts General Hospital (US)
- Keesler Medical Center (US)
Publication Details
- Journal
- ESMO Open
- Published
- 2025-06-24
- DOI
- https://doi.org/10.1016/j.esmoop.2025.105493
- Primary Topic
- Sarcoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Bristol-Myers Squibb
- National Institutes of Health
- University of Texas MD Anderson Cancer Center
- National Cancer Institute