Identification of plasminogen activator urokinase receptor-related non-coding RNA and immune prognostic signature for non-small cell lung cancer
Plasminogen activator urokinase receptor was differently expressed and positively correlated with an unfavorable prognosis in NSCLC. The MIRLET7BHG/hsa-miR-127-3p axis was identified as the most likely upstream ncRNA-related pathway for PLAUR in NSCLC. This study provides insights into the molecular mechanism of action of PLAUR in NSCLC, which may help to develop new drugs to regulate PLAUR expression or its function in tumor development and provide new targets for the treatment of NSCLC.
Authors
- Xihua Jia
- Xianjie Li
- H. Li
- Hao Zhang
- Zhanhai Song
- Shihao Bao
- Yuan Cheng
- Qian-Qian Sun (ORCID: https://orcid.org/0009-0008-4546-0736)
- Yifan Zhang (ORCID: https://orcid.org/0009-0004-4350-1048)
Institutions
- Tianjin Medical University General Hospital (CN)
- Tianjin Medical University Cancer Institute and Hospital (CN)
- Second Hospital of Tangshan (CN)
Publication Details
- Journal
- Clinics
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.clinsp.2025.100711
- Citations
- 2
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 1.87