Intermittent hypoxia aggravates asthma inflammation via NLRP3/IL-1β-dependent pyroptosis mediated by HIF-1α signalling pathway
Obstructive sleep apnoea-hypopnea syndrome (OSAHS) is a risk factor for asthma exacerbation. IH aggravates neutrophil inflammation in asthma via NLRP3/IL-1β-dependent pyroptosis mediated by the HIF-1α signalling pathway, which should be considered a potential therapeutic target for the treatment of asthma with OSAHS.
Authors
- Pengdou Zheng
- Huojun Zhang (ORCID: https://orcid.org/0000-0002-4013-9299)
- Fengqin Zhang (ORCID: https://orcid.org/0000-0001-9479-2456)
- Huiguo Liu (ORCID: https://orcid.org/0000-0002-9722-833X)
- Xiaoyan Zhu (ORCID: https://orcid.org/0000-0002-7998-6444)
- Xiaojing Cai (ORCID: https://orcid.org/0000-0001-7346-6029)
- Guisha Zi
- Lingling Wang (ORCID: https://orcid.org/0000-0002-1049-9170)
- Lu Liu (ORCID: https://orcid.org/0000-0002-1547-4431)
- Wei Liu (ORCID: https://orcid.org/0000-0002-8033-4718)
- Lixiang Chen (ORCID: https://orcid.org/0000-0001-7785-2496)
- Ling Zhou (ORCID: https://orcid.org/0000-0001-6136-5685)
- Zhenyu Mao
Institutions
- Kunming University of Science and Technology (CN)
- Wuhan University (CN)
- First People's Hospital of Yunnan Province (CN)
- Renmin Hospital of Wuhan University (CN)
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Chinese Medical Journal
- Published
- 2025-06-25
- DOI
- https://doi.org/10.1097/cm9.0000000000003608
- Citations
- 4
- Primary Topic
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Type
- article
- Field-Weighted Citation Impact
- 6.07