Integrative multiomic and immune profiling of lung adenocarcinoma: molecular landscapes, gene expression, and treatment response insights
This study identifies 2 LUAD subtypes with distinct molecular and immune features linked to prognosis and therapy response. Neuronal differentiation factor downregulation and its tumor-suppressive effects highlight its therapeutic potential. These findings support improved LUAD stratification and personalized treatment strategies.
Authors
- Suxin Jiang
- Honghong Dong (ORCID: https://orcid.org/0000-0002-0391-4727)
- Yong Han
- Yahui Tian (ORCID: https://orcid.org/0009-0006-2004-554X)
- Shaowei Xin (ORCID: https://orcid.org/0000-0002-7606-134X)
- Huaiyu Wang (ORCID: https://orcid.org/0000-0002-9093-8793)
- Yujie Guo (ORCID: https://orcid.org/0000-0002-2379-0725)
- Zitong Wan (ORCID: https://orcid.org/0009-0004-2527-8997)
Institutions
- Harbin Engineering University (CN)
- Northwest University (CN)
- Logistics Management Institute (United States) (US)
- China Medical University (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- The Oncologist
- Published
- 2025-06-24
- DOI
- https://doi.org/10.1093/oncolo/oyaf191
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Natural Science Foundation of Shandong Province