Enhanced Trained Immunity in Peripheral Monocytes in Unstable Angina With Elevated High-Sensitivity C-Reactive Protein
Despite effective secondary prevention for coronary heart diseases, recurrent events remain high. Elevated high-sensitivity C-reactive protein (hsCRP) indicates increased inflammation risk. This study aimed to investigate the trained immunity of circulating monocytes in unstable angina (UA) patients with elevated hsCRP. We analyzed CD14<sup>+</sup> monocytes from UA patients, comparing high-risk (hsCRP ≥3 mg/L) and low-risk (hsCRP <1 mg/L) groups. We assessed cytokine production and conducted metabolic, transcriptional, and epigenetic profiling. Patients with elevated hsCRP exhibited enhanced proinflammatory responses, glycolytic activity, and altered immune profiles, indicating sustained monocyte trained immunity, which contributes to residual inflammation risk in cardiovascular disease.
Authors
- Xinyi Xia (ORCID: https://orcid.org/0000-0002-7178-0505)
- Qing K. Wang (ORCID: https://orcid.org/0000-0002-5639-8519)
- Fen Yang (ORCID: https://orcid.org/0000-0002-1970-3270)
- Huirong Liu (ORCID: https://orcid.org/0009-0004-0974-8311)
- Zhilei Shan (ORCID: https://orcid.org/0000-0002-6723-3381)
- Weimin Wang (ORCID: https://orcid.org/0000-0002-9852-1589)
- Chen Chen (ORCID: https://orcid.org/0000-0003-2541-6283)
- Li Zhang (ORCID: https://orcid.org/0000-0003-2566-4439)
- Cheng Xiang (ORCID: https://orcid.org/0000-0002-1229-6860)
- Jiyu Zhang (ORCID: https://orcid.org/0000-0002-1758-233X)
- Desheng Hu (ORCID: https://orcid.org/0000-0001-9298-5545)
- Miao Yu (ORCID: https://orcid.org/0000-0002-8298-1679)
- Peter Libby
- Chaolong Wang
- Y.P. Liao (ORCID: https://orcid.org/0000-0002-3151-2063)
Institutions
- Brigham and Women's Hospital (US)
- Union Hospital (HK)
- Harvard University (US)
- Capital Medical University (CN)
- Tongji Hospital (CN)
- Union Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- JACC Basic to Translational Science
- Published
- 2025-06-24
- DOI
- https://doi.org/10.1016/j.jacbts.2025.04.014
- Citations
- 5
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 3.99
Funders
- Huazhong University of Science and Technology