Intermediate-Dose Cytarabine as Postinduction AML Therapy

Our trial shows noninferior outcomes in patients 18 to 60 years of age with newly diagnosed AML treated with low- versus high-dose cytarabine; this occurred with similar or lower toxicities. (Funded by the Regional Clinical Research Office, Angers and others; EudraCT number, 2014-000699-24; ClinicalTrials.gov number, NCT02416388.).

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Publication Details

Journal
NEJM Evidence
Published
2025-06-24
DOI
https://doi.org/10.1056/evidoa2400326
Citations
7
Primary Topic
Acute Myeloid Leukemia Research
Type
article
Field-Weighted Citation Impact
12.39
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article

Intermediate-Dose Cytarabine as Postinduction AML Therapy

Maël Heiblig, Mathilde Hunault, Éric Delabesse, Christian Récher et al.
7 citations
NEJM Evidence
Acute Myeloid Leukemia Research
12.39
article

Intermediate-Dose Cytarabine as Postinduction AML Therapy

Maël Heiblig, Mathilde Hunault, Éric Delabesse, Christian Récher, Isabelle Luquet, Claude Preudhomme, Pierre‐Yves Dumas, Sylvain Chantepie, Pierre Péterlin, Pascal Turlure, Romain Guièze, Émilie Lemasle, Norbert Ifrah, Sarah Bertoli, Anne Huynh, Thibaut Leguay, Cécile Pautas, Norbert Vey, Claude Gardin, Karine Celli‐Lebras, Hervé Dombret, Célestine Simand, Raynier Devillier, Nicole Raus, Nicolas Duployez, Ariane Mineur, Martin Carré, Stéphanie Nguyen Quoc, Tony Marchand, Gérard Socié, Arnaud Pigneux, Jean‐François Hamel, Dominique Penther, Emmanuel Raffoux, Régis Peffault de Latour, J Cahn, Maria-Pilar Gallego-Hernanz
article en
7 citations

Abstract

Our trial shows noninferior outcomes in patients 18 to 60 years of age with newly diagnosed AML treated with low- versus high-dose cytarabine; this occurred with similar or lower toxicities. (Funded by the Regional Clinical Research Office, Angers and others; EudraCT number, 2014-000699-24; ClinicalTrials.gov number, NCT02416388.).

NEJM EvidenceVol. 4(7)
Université Claude Bernard Lyon 1 (FR), Centre National de la Recherche Scientifique (FR), Université Toulouse III - Paul Sabatier (FR), Université de Bordeaux (FR), Inserm (FR), Université Paris-Est Créteil (FR), Université Clermont Auvergne (FR), Université Paris Cité (FR), Université de Lille (FR), Centre Hospitalier Universitaire de Grenoble (FR), Saint Louis University Hospital (US), Centre Hospitalier Universitaire de Bordeaux (FR), Centre Hospitalier Universitaire de Lille (FR), Centre Hospitalier Universitaire de Nantes (FR), Centre Hospitalier Universitaire de Toulouse (FR), Université de Poitiers (FR), Sorbonne Université (FR), Institut de Cancérologie Strasbourg (FR), Centre de Recherche en Cancérologie et Immunologie Intégrée Nantes Angers (FR), Acute Leukemia French Association (FR), Assistance Publique – Hôpitaux de Paris (FR), Institut universitaire du cancer de Toulouse Oncopole (FR), Hospices Civils de Lyon (FR), Fédération Hospitalo-Universitaire, Paris Center for Microbiome Medicine (FR), Normandie Université (FR), Institut de Recherche en Santé, Environnement et Travail (FR), Centre Hospitalier Universitaire de Caen Normandie (FR), Centre Hospitalier Universitaire de Limoges (FR), Pitié-Salpêtrière Hospital (FR), Établissement Français du Sang (FR), Hôpital Avicenne (FR), Centre de Recherche en Cancérologie de Marseille (FR), Hôpital Saint-Louis (FR), Centre Virchow-Villermé (FR), Centre Hospitalier Universitaire de Rennes (FR), Centre International de Recherche en Infectiologie (FR), Centre Henri Becquerel, Microenvironment and B-cells: Immunopathology, Cell, Differentiation and Cancer (FR), BoRdeaux Institute of onCology (FR), Université d'Angers (FR), Université de Rennes (FR), Université de Limoges (FR), Université de Strasbourg (FR), Université Grenoble Alpes (FR), Nantes Université (FR), Université de Caen Normandie (FR)
Zero hunger
Openalex Percentile: Top 1%
Acute Myeloid Leukemia Research
12.39
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