A Vaccine to Block <i>Plasmodium falciparum</i> Transmission
In this trial, Pfs230D1-EPA/AS01 regimens did not result in SAEs and generated antibody responses and functional activity that persisted for up to 1 year postvaccination. Although the primary efficacy estimate did not demonstrate a reduction in parasite transmission during the first 6 weeks of follow-up, the full dosing regimen was associated with reduced transmission events and infected mosquitoes over 2 years. (Funded by the National Institute of Allergy and Infectious Diseases and others; ClinicalTrials.gov ID, NCT02942277.).
Authors
- Amatigué Zéguimé (ORCID: https://orcid.org/0000-0002-3158-1907)
- Ismaila Théra (ORCID: https://orcid.org/0009-0001-3372-9063)
- Issaka Sagara (ORCID: https://orcid.org/0000-0002-8555-9983)
- Jen C. C. Hume
- Jennifer Kwan (ORCID: https://orcid.org/0000-0002-7176-6340)
- Jonathan Fintzi (ORCID: https://orcid.org/0000-0002-6361-702X)
- Rathy Mohan
- Mamadou B. Coulibaly (ORCID: https://orcid.org/0000-0001-9325-2845)
- Alemush Imeru
- Patrick E. Duffy (ORCID: https://orcid.org/0000-0002-4483-5005)
- Irfan Zaidi (ORCID: https://orcid.org/0000-0001-9161-2050)
- David L. Narum (ORCID: https://orcid.org/0000-0003-3041-5402)
- Danielle Morelle
- Justin Doritchamou (ORCID: https://orcid.org/0000-0002-4589-7216)
- Nicholas J. MacDonald (ORCID: https://orcid.org/0000-0002-8162-4514)
- Gail E. Potter (ORCID: https://orcid.org/0000-0001-6667-6992)
- Bruce Swihart (ORCID: https://orcid.org/0000-0002-4216-9942)
- Abdoulaye Katilé (ORCID: https://orcid.org/0000-0003-0531-3682)
- Sara A. Healy (ORCID: https://orcid.org/0000-0003-3078-6094)
- Kelly M. Rausch (ORCID: https://orcid.org/0000-0003-2270-4319)
- Daming Zhu (ORCID: https://orcid.org/0000-0001-7397-2685)
- Mamady Koné (ORCID: https://orcid.org/0000-0002-9847-2115)
- Marc Lievens
- Mahamadoun H. Assadou
- Balla Diarra
- Robert Morrison
- Ogobara K. Doumbo
- Amagana Dolo
- Daman Sylla
Institutions
- National Institutes of Health (US)
- GlaxoSmithKline (Belgium) (BE)
- Université des Sciences, des Techniques et des Technologies de Bamako (ML)
- National Institute of Allergy and Infectious Diseases (US)
Publication Details
- Journal
- NEJM Evidence
- Published
- 2025-06-24
- DOI
- https://doi.org/10.1056/evidoa2400188
- Citations
- 7
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 13.15