Does treatment of adolescent depression reduce risk of later psychosis: A quasi-experimental study of selective serotonin reuptake inhibitor treatment in a total population cohort
Our quasi-experimental investigation does not support the hypothesis that treatment of adolescent depression reduces the subsequent risk of psychosis. Our findings question the assumption that treatment of common mental health disorders in youth may impact the risk of developing severe mental illnesses in adulthood.
Authors
- Martta Kerkelä (ORCID: https://orcid.org/0000-0002-1181-2632)
- Kirstie O’Hare (ORCID: https://orcid.org/0000-0002-1166-9792)
- Colm Healy (ORCID: https://orcid.org/0000-0001-7974-1861)
- Jonah F. Byrne (ORCID: https://orcid.org/0000-0002-7046-0630)
- Anna Pulakka (ORCID: https://orcid.org/0000-0002-0602-8632)
- Ian Kelleher (ORCID: https://orcid.org/0000-0003-1484-651X)
- Johanna Metsälä (ORCID: https://orcid.org/0000-0003-3806-1020)
- Ulla Lång (ORCID: https://orcid.org/0000-0002-1399-0635)
- Eero Kajantie
- Juha Veijola
Institutions
- University College Dublin (IE)
- Norwegian University of Science and Technology (NO)
- Oulu University Hospital (FI)
- Finnish Institute for Health and Welfare (FI)
- St John of God Hospital (AU)
- Oulu University of Applied Sciences (FI)
- University of Oulu (FI)
- University of Edinburgh (GB)
Publication Details
- Journal
- European Psychiatry
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1192/j.eurpsy.2025.10050
- Citations
- 1
- Primary Topic
- Child and Adolescent Psychosocial and Emotional Development
- Type
- article
- Field-Weighted Citation Impact
- 2.31
Funders
- Health Research Board
- Academy of Medical Sciences