AP-1-dependent c-Fos activation by TREX1 drives M2 macrophage polarization and mitigates osteoarthritis progression
Overall, TREX1's influence on macrophage polarization affects chondrocyte function and cartilage homeostasis, making it a potential therapeutic target for OA treatment.
Authors
- Nirong Bao
- Shanbang Zhu
- Jiabin Yuan (ORCID: https://orcid.org/0000-0003-0823-1359)
- Lei Zhang (ORCID: https://orcid.org/0000-0001-6302-8383)
- Kai Chen (ORCID: https://orcid.org/0000-0001-6850-1723)
- Hao Ding (ORCID: https://orcid.org/0000-0001-8456-8311)
- Chang Sun (ORCID: https://orcid.org/0000-0002-0806-6341)
- Xinzhe Feng (ORCID: https://orcid.org/0000-0003-4176-494X)
- Yang Wang (ORCID: https://orcid.org/0000-0003-0138-5523)
- Enning Cui
Institutions
- Second Military Medical University (CN)
- Changhai Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Cellular and Molecular Life Sciences
- Published
- 2025-06-25
- DOI
- https://doi.org/10.1007/s00018-025-05771-0
- Citations
- 4
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 3.19
Funders
- Foundation Research Project of Jiangsu Province