Risk factors for development of diabetic foot ulcer disease in two large contemporary <scp>UK</scp> cohorts
In the English cohort, 4.7% developed DFUD over a median of 4.3years (incidence rate 9.0[95%CI: 8.8-9.2] per 1000 person-years) follow-up; in the Scottish cohort, the equivalent figure was 2.9% over a median of 6.3 years (incidence rate 4.4 [95% CI: 4.3-4.5] per 1000 person-years). Despite different methods of case ascertainment, multivariable analysis in both populations indicated that those who developed DFUD were more likely to be older, male, smokers, of White ethnicity, with higher systolic blood pressure and baseline HbA1c. These findings provide a robust evidence base for identifying people with diabetes at risk of DFUD for targeted efforts for prevention.
Authors
- Graham Leese (ORCID: https://orcid.org/0000-0003-0570-5678)
- Bethany Stanley (ORCID: https://orcid.org/0000-0003-3299-4014)
- Jonathan Valabhji
- Jiyoung Lee (ORCID: https://orcid.org/0000-0001-6942-378X)
- Philipp S. Wild (ORCID: https://orcid.org/0000-0003-4413-9752)
- Daniel Pollard (ORCID: https://orcid.org/0000-0001-5630-0115)
- Solomon Tesfaye (ORCID: https://orcid.org/0000-0003-1190-1472)
- Nicola Greenlaw (ORCID: https://orcid.org/0000-0003-3847-1126)
- Alan Brennan (ORCID: https://orcid.org/0000-0002-1025-312X)
- Clare L. Gillies (ORCID: https://orcid.org/0000-0002-8417-9700)
- Patrick Highton (ORCID: https://orcid.org/0000-0002-0410-5788)
- Frances L. Game (ORCID: https://orcid.org/0000-0002-5294-4789)
- Sharmin Shabnam (ORCID: https://orcid.org/0000-0002-2519-1240)
- Safoora Gharibzadeh (ORCID: https://orcid.org/0000-0003-4535-4040)
- John R. Petrie (ORCID: https://orcid.org/0000-0002-4894-9819)
- Edward W. Gregg (ORCID: https://orcid.org/0000-0003-2381-6822)
- Francesco Zaccardi (ORCID: https://orcid.org/0000-0002-2636-6487)
- Kamlesh K. Khunti (ORCID: https://orcid.org/0000-0003-2343-7099)
- Melanie Jane Davies (ORCID: https://orcid.org/0000-0002-9987-9371)
- David J. Webb (ORCID: https://orcid.org/0000-0001-9593-0320)
- Laura Schaffner Gray
Institutions
- University of Leicester (GB)
- University of Derby (GB)
- Leicester General Hospital (GB)
- NHS Tayside (GB)
- National Institute for Health and Care Research (GB)
- Sheffield Teaching Hospitals NHS Foundation Trust (GB)
- Chelsea and Westminster Hospital (GB)
- NIHR Leicester Biomedical Research Centre (GB)
- Imperial College London (GB)
- University of Glasgow (GB)
- University of Sheffield (GB)
- University of Edinburgh (GB)
Publication Details
- Journal
- Diabetes Obesity and Metabolism
- Published
- 2025-06-24
- DOI
- https://doi.org/10.1111/dom.16519
- Citations
- 3
- Primary Topic
- Diabetic Foot Ulcer Assessment and Management
- Type
- article
- Field-Weighted Citation Impact
- 3.88
Funders
- National Institute for Health and Care Research