Bioresponsive Hyaluronic Acid‐Based Hydrogel Inhibits Matrix Metalloproteinase‐2 in Glioblastoma Microenvironment
Glioblastoma multiforme (GBM) is an extremely malignant cancer, resistant to standard therapies. Tumor resection is associated with better outcomes but a complete resection of GBMs is challenging for anatomical limitation and for the high degree of invasiveness. A bioresponsive hydrogel based on hyaluronic acid (HA) cross-linked with a branched metalloproteinase (MMP) inhibitor (MMPI) is proposed. The fully characterized hydrogel, HA-MMPI, presents physical properties suitable for filling the surgical resection cavity and for in situ delivery of the inhibitor. The bioresponsive material selectively inhibits MMP-2 versus MMP-9 in glioblastoma microenvironment.
Authors
- Domenico Salerno (ORCID: https://orcid.org/0000-0001-8160-8349)
- Laura Russo (ORCID: https://orcid.org/0000-0002-5914-766X)
- Gemma Leone (ORCID: https://orcid.org/0000-0002-0820-6068)
- Francesco Mantegazza (ORCID: https://orcid.org/0000-0003-4257-2165)
- Luca Crippa (ORCID: https://orcid.org/0000-0003-1492-9542)
- Federica Barbugian (ORCID: https://orcid.org/0000-0002-9156-9571)
- Luigi Talarico (ORCID: https://orcid.org/0000-0002-8553-3521)
- E Ballarini (ORCID: https://orcid.org/0000-0002-1678-6357)
- Stefano Roelens (ORCID: https://orcid.org/0000-0002-9763-3263)
- Cristina Nativi (ORCID: https://orcid.org/0000-0002-6312-3230)
- Agnese Magnani (ORCID: https://orcid.org/0000-0002-6960-9418)
- Simone Pepi (ORCID: https://orcid.org/0000-0002-3290-9644)
- Oscar Francesconi (ORCID: https://orcid.org/0000-0002-6155-4926)
- Guido Cavaletti (ORCID: https://orcid.org/0000-0003-4128-2406)
Institutions
- University of Siena (IT)
- National Interuniversity Consortium of Materials Science and Technology (IT)
- University of Florence (IT)
- University of Milano-Bicocca (IT)
Publication Details
- Journal
- ChemMedChem
- Published
- 2025-06-24
- DOI
- https://doi.org/10.1002/cmdc.202401040
- Citations
- 4
- Primary Topic
- Proteoglycans and glycosaminoglycans research
- Type
- article
- Field-Weighted Citation Impact
- 4.61
Funders
- Dipartimenti di Eccellenza
- Università degli Studi di Firenze