Vanishing bile duct syndrome in a psychiatric patient with severe cannabis use

Abstract Vanishing bile duct syndrome is a rare hepatic complication with multiple aetiologies that can result in poor patient outcomes if left undiagnosed and untreated. Certain factors are well-researched and understood to increase the risk of developing this syndrome, but other possible causes, such as cannabis, are less well-documented. Patients with psychiatric disorders face compounded risks of liver injury due to polypharmacy, lifestyle choices, and substance use, and thus represent a population at risk of developing such complications. We present the case of a psychiatric patient who developed vanishing bile duct syndrome with a history of severe, prolonged cannabis use.