Identification of hub genes involved in the pathogenesis of diabetic nephropathy: A multi‐omics study integrating machine learning, mendelian randomization and mediation analysis
Through comprehensive bioinformatics analysis and experimental validation, we identified THBS2 as a potential diagnostic marker for DN. These findings provide new insights into DN pathogenesis and suggest directions for future therapeutic strategies.
Authors
- Yanqing Wang (ORCID: https://orcid.org/0000-0002-8072-8899)
- Kang Li (ORCID: https://orcid.org/0000-0002-2213-5489)
- Huidi Tang
- Xiaojie Wang (ORCID: https://orcid.org/0000-0002-7121-5768)
Institutions
- Allen Institute for Brain Science (US)
- Mount Sinai Hospital (US)
- Shandong University (CN)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Diabetes Obesity and Metabolism
- Published
- 2025-06-24
- DOI
- https://doi.org/10.1111/dom.16536
- Citations
- 4
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 7.27
Funders
- Natural Science Foundation of Shandong Province