Metal–Organic Framework-Based Self-Powered Chemodynamic Therapy Nanosystem: CaO₂@PCN-222(Fe) and Its Mixed Matrix Membranes for Promoting Infected Wound Healing

Bacterial infections pose an increasing threat to human health. Chemodynamic therapy (CDT), which utilizes nanozymes to catalyze H₂O₂ into highly toxic hydroxyl radicals (·OH), offers a promising disinfection strategy because of its high efficacy, broad-spectrum antibacterial activity, and low risk of inducing drug resistance. Herein, we developed a self-powered CDT nanocomposite, CaO₂@PCN-222(Fe), via a facile one-pot synthesis for wound disinfection. In infected wounds, the CaO₂ component of the composite gradually hydrolyzes to H₂O₂, while the PCN-222(Fe) component acts as peroxidase mimics to efficiently catalyze the generated H₂O₂ into ·OH, thus achieving self-powered CDT. In vitro assays confirmed that the minimum bactericidal concentration of the composite against <i>Staphylococcus aureus</i> is as low as 31.25 μg mL^-1. Furthermore, in vivo assays demonstrated that the composite could effectively accelerate infected wound healing. To broaden application scenarios, the composite was further integrated into poly(vinylidene fluoride) (PVDF) to form CaO₂@PCN-222(Fe)@PVDF mixed matrix membranes (MMMs), which inherit the self-powered CDT capability, exhibiting high antimicrobial activity and promoting infected wound healing. Notably, no significant toxicity was observed for CaO₂@PCN-222(Fe) and its MMMs. This work presents an efficient self-powered CDT modality, combining the advantages of CaO₂ and peroxidase mimics for treating bacterial infections and promoting infected wound healing.