Inhibition of spreading depolarizations by targeting GABA<sub>A</sub> receptors and voltage‐gated sodium channels improves neurological deficits in rats with traumatic brain injury
Targeting both Na<sub>V</sub>s and GABA<sub>A</sub> receptors can overcome limitations associated with single-target approaches, providing valuable insights and critical clues for drug discovery in TBI and offering a promising therapeutic strategy for other neurological disorders involving SDs, such as stroke and subarachnoid haemorrhage.
Authors
- Qi Liu (ORCID: https://orcid.org/0000-0002-3000-7559)
- Shengjun Mao (ORCID: https://orcid.org/0000-0002-8712-3040)
- Yao Nie (ORCID: https://orcid.org/0000-0001-8065-7640)
- Di Zhang (ORCID: https://orcid.org/0000-0001-6305-2754)
- Kai Li (ORCID: https://orcid.org/0000-0002-8782-0823)
- Yingying Zhang (ORCID: https://orcid.org/0000-0001-5746-8200)
- Hui Li
- Li Yue (ORCID: https://orcid.org/0000-0003-3103-0213)
- Ruijie Yan
- Pengyu Li (ORCID: https://orcid.org/0000-0003-2030-1807)
Institutions
- University of Electronic Science and Technology of China (CN)
- Sichuan University (CN)
- West China Medical Center of Sichuan University (CN)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2025-06-24
- DOI
- https://doi.org/10.1111/bph.70117
- Citations
- 4
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 3.64